• Duration: 14 nights
  • Distance (approx): 1482 miles
  • Price: Call for info
Save this Tailor-Made Fly-Drive holiday in The Great Lakes, USA
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The Great Mississippi River Road

A Tailor-Made Fly-Drive Holiday to The Great Lakes, USA

Arrive in Minneapolis located on the beautiful Great River Road renowned for its culture, shopping and entertainment. Explore the scenic byways surrounding the city that showcase its beautiful lakes and parkways. Trace the Mississippi to the pretty river town of La Crosse before arriving in Galena, a charming town full of 19th century buildings and evidence of the steam boating era. 

Your journey continues along the river to Nauvoo, boasting over 60 restored historic sites and museums. Arrive in Hannibal where the legacy of Mark Twain is alive and well before heading south to the historic town of Alton at the confluence of three mighty rivers.

Continuing to shadow the mighty Mississippi you will arrive at the charming village of Ste Genevieve deep in the heart of the Chaumette Vineyards. Your route then heads south via Memphis and Vicksburg to New Orleans where you will catch your flight home.


Enjoy a cruise on a nostalgic riverboat and follow in the footsteps of Mark Twain

At the confluence of the Mississippi, Illinois and Missouri rivers.

La Crosse
Full of historic buildings set in picturesque scenery with excellent bird watching.

A shopping mecca surrounded by lakes and parkways

Chaumette Vineyards and Winery
Take a tour and sample the wines.

Great River Road
Follow the meandering Mississippi with its fantastic scenery

Grand Rounds Scenic Byway
Drive around the stunning parks and lakes surrounding Minneapolis

Minnesota River Valley Scenic Byway
Explore rich history with rolling hills, lush forests and sparkiling rivers

To Book This Holiday or find out more call our Travel Specialists on: 01902 798008 or contact us online.
Tailor-Made Fly-Drive The Great Mississippi River Road in The Great Lakes, USA
Tailor-Made Fly-Drive The Great Mississippi River Road in The Great Lakes, USA
Carriage ride in Galena

Related Brochures

Featured accommodation

Reagan’s Queen Anne B&B

Reagan's Queen Anne Historic Bed and Breakfast is the perfect place for your overnight stay. We're centrally located just 3 blocks from downtown shops, restaurants, the Planter's Barn Theater, and museums.

Additional accommodation

Westby House B&B

Westby, Wisconsin


Minneapolis Double Tree Hotel
2 Nights
159 miles to La Crosse

Westby House B&B
2 Nights
135 miles to Galena

Farmers Guest House B&B
1 Night
191 miles to Nauvoo

Ellis Sanders House B&B
1 Night
84 miles to Hannibal

Reagan’s Queen Anne B&B
2 Nights
132 miles to Alton

Jackson House B&B
2 Nights
64 miles to Ste Genevieve

Main Street Inn 
1 Night
234 miles to Memphis

Baymont Inn & Suites
1 Night
254 miles to Vicksburg

Quality Inn & Suites
1 Night
229 miles to New Orleans

Courtyard Hotel
1 Night

Voted top guide book series by Wanderlust Travel Awards and endorsed by Michael Palin, we offer a visually stunning FREE DK guide book packed with information once you have confirmed your holiday.

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